Anavar: results, dosage and side effects

Trade names:

Anavar (“Searle” USA)

Anatrofill (“Searle” USA)

Lonavar (“Searle” Argentina)

Lonavar (“Searle” Japan)

Vasorom 0,5 (“Kowa” Japan)

Lipideks (“Searle” Brazil)

Oxandrolone SPA (“SPA” Spain)

Anavar 0,05 (“Hubei Huangshi Nanshang Co., China”)

Of these the first three brands currently discontinued. The preparation is mainly produced in the form of pellets with a concentration of 2.5 mg of active substance. Japanese analogue has the same dosage of 2 mg., And Chinese – 5 mg.

The active chemical compound: Oxandrolone

Background: The drug was developed by the pharmaceutical company Searle Laboratories, and released under the trademark Anavar in 1964 in the United States. 01.07.1986 of release of the drug was suspended, but resumed the other companies in China, Japan and South American countries.

Pharmacological action of pharmacotherapeutic designation refers to anabolic steroid drugs. It stimulates the synthesis of protein upon binding to specific nuclear receptors, also delays the excretion of substances necessary for the process: potassium ions, sulfur, phosphates, and other proteins, which is the cause of a positive nitrogen balance while taking the drug. It accelerates tissue regeneration, increases the body weight due to the growth of muscle and bone mass. The anabolic effect of the preparation is superior to that of natural testosterone levels more than 10 times. The advantage lies in the absence of drug effects aromatization to estrogen conversion, and their derivatives, because of which the list is greatly reduced side effects. In addition it has low androgenic activity, which also has a favorable effect on the production of endogenous sex hormones.

Indications:

  • cachexia of various nature;
  • congenital / acquired disorders of protein metabolism due to prolonged use of glucocorticoid therapy or radiation, extensive burns and severe traumatic injuries, chronic infectious diseases involving the loss of proteins, as well as muscular dystrophy;
  • diabetic angiopathy;
  • when the need to accelerate tissue regeneration in the recovery period of fractures and injuries;
  • stunted growth of the child as a result of Turner’s syndrome or pituitary dwarfism;
  • delayed puberty and physical development of boys (sexual infantilism);
  • encephalopathy as a complication of advanced alcoholic hepatitis.

Contraindications to the use of the drug are:

  • hypersensitivity to the drug;
  • breast cancer in women, accompanied by hypercalcemia, prostate cancer and breast cancer in men;
  • severe degree of liver disease;
  • urinary system diseases (nephrosis, glomerulonephritis and nephrotic stage);
  • is absolutely contraindicated during pregnancy!

oxandrolonUse with caution and under strict medical supervision at:

  • heart, liver or kidney failure;
  • atherosclerosis of the coronary arteries;
  • diabetes;
  • or acute myocardial infarction;

It is also not recommended to take the drug in the elderly, children or adolescents, because it may cause premature epiphyseal cartilage ossification, early puberty and virilization girls.

Data on the effect of the drug on women during lactation are not available.

The drug has a sufficient number of side effects, including:

  • progression of atherosclerosis due to violation of HDL ratio and a low density plasma;
  • high risk leukemoid syndrome and iron deficiency anemia, frequent bleeding;
  • during prolonged therapy uncontrolled – purple liver, liver cirrhosis, hepatocellular carcinoma, cholestatic hepatitis;
  • increased secretion of sweat and sebaceous glands, multiple dermal hemorrhage;
  • diarrheal disorders, including diarrhea and flatulence;
  • violation of libido, regulation of sleep, convulsions;
  • disorders of puberty in children, virilism women;

Dosing of the drug:

  • The average dose for adults – 1 tablet administration (2.5 mg) of 2 to 4 times a day, for children – 0.25 mg per kg per body weight of the child;
  • In the treatment of Turner syndrome – 0.05 – 0.125 mg per kg body weight;
  • In the treatment of delayed growth and development in males, including and sexual – 0.1 mg per kg of body weight, the rate ranges from 3 months to a year;

Duration of the course depends on the manifestation of the therapeutic effect, supervised by a physician.

Notes: reception Anavar (oxandrolone) should be carried out under the control of the concentration of calcium, cholesterol and blood glucose. When the first side effects is necessary to suspend the treatment and consult a doctor.